Miyazawa T, Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M
Laboratory of Food and Biodynamic Chemistry, Graduate School of Life Science and Agriculture, Tohoku University, Sendai, 981-8555, Japan.
Biochemistry (Mosc). 2004 Jan;69(1):67-9. doi: 10.1023/b:biry.0000016353.18007.39.
Modulation of angiogenesis is now a recognized strategy for the prevention of various angiogenesis-mediated disorders. We investigated, using well-characterized in vitro systems, the anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, a natural analog of tocopherol. Tocotrienol, but not tocopherol, inhibited the proliferation of bovine aortic endothelial cells in dose dependent manner at half-maximal concentrations in the low micromolar range. Tocotrienol also significantly inhibited the formation of networks of elongated endothelial cells within 3D collagen gels. From these results, we suggest that tocotrienol is a potential candidate for the development of useful therapeutic agents or preventive food factors for tumor angiogenesis.
调节血管生成现已成为预防各种血管生成介导疾病的公认策略。我们使用特征明确的体外系统，研究了维生素E化合物的抗血管生成特性，尤其着重于生育三烯酚，它是生育酚的天然类似物。生育三烯酚而非生育酚，在低微摩尔范围内以半最大浓度呈剂量依赖性方式抑制牛主动脉内皮细胞的增殖。生育三烯酚还显著抑制三维胶原凝胶内细长内皮细胞网络的形成。基于这些结果，我们认为生育三烯酚是开发用于肿瘤血管生成的有效治疗剂或预防性食品因子的潜在候选物。
