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[坎塔布里亚婴幼儿群体中的肺炎球菌性脑膜炎]

[Pneumococcal meningitis in the infantile population of Cantabria].

作者信息

Alonso Palacio J, Madrigal Díez V, García Fuentes M

机构信息

Departamento de Pediatría, Hospital Nacional Marqués de Valdecilla, Facultad de Medicina, Santander.

出版信息

An Esp Pediatr. 1992 Jun;36(6):441-5.

PMID:1497225
Abstract

A retrospective study of pneumococcal meningitis was carried out. This study included 22 cases of this illness that occurred in 17 pediatric patients in Cantabria between 1977 and 1990, inclusive. Three children suffered from recurrent meningitis. The age range of the patients was 0.3-14 years, with a mean age of 4 years. Of these cases, 77.4% occurred in the winter or spring. In 14 cases of meningitis (63.6%), corresponding to 9 patients, underlying pathology was observed: cranial fracture, occipital dermoid cyst, splenectomy, congenital cardiopathy, epilepsy and gastroduodenal "situs inversus". The isolated pneumococci were found to be resistant to penicillin and chloramphenicol in 4 cases. One patient suffered from septic shock. The outcome was complete recovery in 19 cases (86.4%), recovery with sequelae (deafness and epilepsy, respectively) in 2 cases (9.1%) and death in another 2 cases. CSF protein levels elevated above 150 mg/dl and the absence of glucose in the CSF were found to be the most useful analytical indicators of the seriousness of the illness.

摘要

开展了一项关于肺炎球菌性脑膜炎的回顾性研究。该研究纳入了1977年至1990年(含)期间在坎塔布里亚17名儿科患者中发生的22例该疾病。三名儿童患有复发性脑膜炎。患者年龄范围为0.3至14岁,平均年龄为4岁。在这些病例中,77.4%发生在冬季或春季。在14例脑膜炎病例(63.6%)中,对应9名患者,观察到有潜在病理情况:颅骨骨折、枕部皮样囊肿、脾切除术、先天性心脏病、癫痫和胃十二指肠“内脏反位”。分离出的肺炎球菌在4例中被发现对青霉素和氯霉素耐药。一名患者发生感染性休克。结果为19例(86.4%)完全康复,2例(9.1%)分别伴有后遗症(耳聋和癫痫)康复,另外2例死亡。脑脊液蛋白水平升高至150mg/dl以上以及脑脊液中无葡萄糖被发现是该疾病严重程度最有用的分析指标。

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