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[食管闭锁及相关畸形]

[Esophageal atresia and associated anomalies].

作者信息

Cano Garci-Nuño A, Solís Sánchez G, Coto Cotallo G D, Cepeda Martínez A, Ramos Aparicio A, López Sastre J, Crespo Hernández M

机构信息

Servicio de Neonatología, Hospital Central de Asturias, Facultad de Medicina, Oviedo.

出版信息

An Esp Pediatr. 1992 Jun;36(6):455-9.

PMID:1497227
Abstract

Twenty-seven newborns with esophageal atresia were reviewed for the presence of other congenital associated anomalies. The incidence of esophageal atresia was 2.6 cases for every 10,000 live births. Associated anomalies were present in 59.25% of these cases. Cardiac malformations were the most frequent associated defect (40.7%). Ten infants met the criteria for VACTERL association. The birth weights and gestational ages were similar for both the surviving and deceased infants. Broncho-aspiration was the only significant factor associated with mortality: 75% of the infants who had broncho-aspiration died, versus only 26.3% if aspiration was not present. When associated anomalies were present, mortality was 56.25%, whereas only 18.18% of the infants without these anomalies died (p = 0.055). We conclude that only broncho-aspiration and associated anomalies relate to mortality in esophageal atresia, whereas the birth weight, the other Waterston's prognosis factor, is not important.

摘要

对27例食管闭锁新生儿进行检查,以确定是否存在其他先天性相关畸形。食管闭锁的发病率为每10000例活产中有2.6例。这些病例中有59.25%存在相关畸形。心脏畸形是最常见的相关缺陷(40.7%)。10例婴儿符合VACTERL综合征的标准。存活和死亡婴儿的出生体重和孕周相似。支气管吸入是与死亡率相关的唯一重要因素:发生支气管吸入的婴儿中有75%死亡,而未发生吸入的婴儿死亡率仅为26.3%。存在相关畸形时,死亡率为56.25%,而无这些畸形的婴儿死亡率仅为18.18%(p = 0.055)。我们得出结论,在食管闭锁中,只有支气管吸入和相关畸形与死亡率有关,而出生体重这一沃特斯顿其他预后因素并不重要。

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