Micheli A, Baldasseroni A, Bruzzi P, Faggiano F, Gatta G, Ivaldi C, Magnani C, Merletti F, Ninu B, Sant M
Divisione di Epidemiologia, Istituto Nazionale Tumori, Milano.
Ann Ist Super Sanita. 1992;28(1):71-90.
Population survival studies are usually carried out within population-based cancer registries and are useful mainly for geographical and temporal survival comparisons. Survival studies based on clinical series of patients are traditionally executed to evaluate the efficacy of a given treatment or to analyze the prognostic role of clinical factors. Subjects from a case-control study on incidence of larynx and hypopharynx cancers in Turin, for the period 1979-82, were followed-up in order to study their survival. The analysis was based on 347 cases of larynx cancer (319 males and 28 females) and 48 cases of hypopharynx cancer (47 males and 1 female). For larynx cancer, observed five-years survival was 59% in males and 64% in females. Hypopharynx cancer had a worse prognosis (21%). In males suffering from larynx cancer, older age, extent of spread, birth in Northern Italy, and being unmarried proved to be statistically significant negative prognostic factors. The same variables were also predictive of survival for hypopharynx cancer. The one- and three-year relative survival for larynx cancer in Turin was higher than that reported by other cancer registries. For males, relative five-year survival figures range from 47% to 65%. Survival for hypopharynx cancer is considerably lower, five-year figures ranging from 13% to 35%. The survival study on lung cancer was based on all the incident cases recorded by the Lombardy Cancer Registry (L.C.R.) from 1976 to 1981; during this period there were 2042 cases of primary lung cancers occurred in males and 217 in females. Observed survival at one, three and five years from diagnosis was 29%, 8% and 5%, respectively. Survival decreased with increasing age; no important differences between sexes are evident. Information on tumor stage was available in 1904 cases and histotype was known in 1605. Three-year survival was 17% for localized tumors, 8% for tumors with regional metastasis, and 1% for tumours with distant metastasis. Epidermoid carcinomas had a better prognosis than non-epidermoid carcinomas in the first year of follow-up, survival being 38% and 29%, respectively; among non-epidermoid carcinomas the worst prognosis was for small-cell carcinomas. Comparisons between the LCR relative survival and that reported by other cancer registries did not show important differences, five-year figures ranging from 5% to 10% in males.(ABSTRACT TRUNCATED AT 400 WORDS)
人群生存研究通常在基于人群的癌症登记处开展，主要用于地理和时间上的生存比较。传统上，基于患者临床系列的生存研究用于评估特定治疗的疗效或分析临床因素的预后作用。对都灵1979 - 1982年期间喉癌和下咽癌发病率的病例对照研究中的受试者进行了随访，以研究他们的生存情况。分析基于347例喉癌病例（319例男性和28例女性）和48例下咽癌病例（47例男性和1例女性）。对于喉癌，男性的五年观察生存率为59%，女性为64%。下咽癌的预后较差（21%）。在患有喉癌的男性中，年龄较大、扩散程度、出生在意大利北部以及未婚被证明是具有统计学意义的负面预后因素。相同的变量也可预测下咽癌的生存情况。都灵喉癌的一年和三年相对生存率高于其他癌症登记处报告的生存率。对于男性，五年相对生存率在47%至65%之间。下咽癌的生存率则低得多，五年生存率在13%至35%之间。肺癌生存研究基于伦巴第癌症登记处（L.C.R.）1976年至1981年记录的所有发病病例；在此期间，男性发生2042例原发性肺癌，女性发生217例。从诊断起观察到的一年、三年和五年生存率分别为29%、8%和5%。生存率随年龄增加而降低；性别之间无明显重要差异。1904例病例有肿瘤分期信息，1605例病例知道组织学类型。局限性肿瘤的三年生存率为17%，有区域转移的肿瘤为8%，有远处转移的肿瘤为1%。在随访的第一年，表皮样癌的预后优于非表皮样癌，生存率分别为38%和29%；在非表皮样癌中，小细胞癌的预后最差。LCR相对生存率与其他癌症登记处报告的生存率之间的比较未显示出重要差异，男性五年生存率在5%至10%之间。（摘要截短至400字）
