Sharma Vivek R, Fleming Donald R, Yam Lung T
University of Louisville, Medical Oncology/Hematology, 529 S. Jackson Street, Louisville, KY 40202, USA.
Hematology. 2002 Aug;7(4):253-8. doi: 10.1080/1024533021000049574.
Langerhans cell histiocytosis (LCH) is an intriguing disorder characterized by the accumulation of specialized dendritic cells called Langerhans cells in several diverse tissues and body sites. It has been cited in numerous case reports to be associated with a wide variety of malignant neoplasms. Although many hypotheses have been suggested, the basis for such associations remains essentially unknown. We describe another association here that to our knowledge has not been reported thus far: a solitary plasmacytoma occurring at a site of previous involvement by LCH. This constitutes a new addition to the now fairly lengthy list of malignant neoplasms that have been reported to occur in the setting of LCH. The possible reasons for such an association are discussed along with a brief review of LCH.
朗格汉斯细胞组织细胞增多症（LCH）是一种引人关注的疾病，其特征是在多种不同组织和身体部位中积累一种名为朗格汉斯细胞的特殊树突状细胞。众多病例报告表明它与多种恶性肿瘤有关。尽管已提出许多假说，但这种关联的基础基本上仍不清楚。我们在此描述另一种关联，据我们所知，迄今为止尚未有相关报道：在先前LCH累及部位出现的孤立性浆细胞瘤。这是在现已相当长的与LCH相关的恶性肿瘤报告清单中新增的一例。本文在简要回顾LCH的同时，讨论了这种关联的可能原因。
