枯草芽孢杆菌中参与硫胺素焦磷酸和磷酸吡哆醛生物合成的两种激酶的特性：4-氨基-5-羟甲基-2-甲基嘧啶激酶和磷酸吡哆醛激酶。
Characterization of two kinases involved in thiamine pyrophosphate and pyridoxal phosphate biosynthesis in Bacillus subtilis: 4-amino-5-hydroxymethyl-2methylpyrimidine kinase and pyridoxal kinase.
作者信息
Park Joo-Heon, Burns Kristin, Kinsland Cynthia, Begley Tadhg P
机构信息
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
出版信息
J Bacteriol. 2004 Mar;186(5):1571-3. doi: 10.1128/JB.186.5.1571-1573.2004.
Abstract
Two Bacillus subtilis genes encoding two proteins (currently annotated ThiD and YjbV) were overexpressed and characterized. YjbV has 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase activity and should be reannotated ThiD, and B. subtilis ThiD has pyridoxine, pyridoxal, and pyridoxamine kinase activity and should be reannotated PdxK.
摘要
编码两种蛋白质（目前注释为ThiD和YjbV）的两个枯草芽孢杆菌基因被过表达并进行了表征。YjbV具有4-氨基-5-羟甲基-2-甲基嘧啶和4-氨基-5-羟甲基-2-甲基嘧啶焦磷酸激酶活性，应重新注释为ThiD，而枯草芽孢杆菌的ThiD具有吡哆醇、吡哆醛和吡哆胺激酶活性，应重新注释为PdxK。
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