一种二价糖簇合物的合成与X射线单晶结构
Synthesis and X-ray single crystal structure of a bivalent glycocluster.
作者信息
Tosin Manuela, Müller-Bunz Helge, Murphy Paul V
机构信息
Centre for Synthesis and Chemical Biology, Department of Chemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
Chem Commun (Camb). 2004 Mar 7(5):494-5. doi: 10.1039/b313934d. Epub 2004 Jan 28.
DOI:10.1039/b313934d
PMID:14973574
Abstract
The crystal structure of a bivalent glycocluster containing aromatic amides reveals that alkylation of secondary amides alters amide configuration and thus carbohydrate presentation. This also facilitates non covalent interactions (azide-azide, carbonyl-pyranose and aromatic-pyranose) and thus carbohydrate-carbohydrate stacking.
摘要
一种含有芳香酰胺的二价糖簇的晶体结构表明，仲酰胺的烷基化改变了酰胺构型，进而改变了碳水化合物的呈现方式。这也促进了非共价相互作用（叠氮-叠氮、羰基-吡喃糖和芳香-吡喃糖），从而促进了碳水化合物-碳水化合物堆积。
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