环丙基脂肪酸表明在细胞色素P450BM3催化的羟基化反应中，中间体是自由基而非阳离子。
Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations.
作者信息
Cryle Max J, Stuthe Julia M U, Ortiz de Montellano Paul R, De Voss James J
机构信息
Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia 4072.
出版信息
Chem Commun (Camb). 2004 Mar 7(5):512-3. doi: 10.1039/b315911f. Epub 2004 Jan 27.
DOI:10.1039/b315911f
PMID:14973583
Abstract
Novel cyclopropyl containing fatty acids are good substrates for P450(BM3) catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 10(10) s(-1)) and the absence of any cationic intermediate.
摘要
新型含环丙基脂肪酸是P450（BM3）催化羟基化反应的良好底物，对其氧化产物的分析表明存在自由基中间体（最大回跳速率为2.6×10(10) s(-1)）且不存在任何阳离子中间体。
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