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脑出血:手术治疗与个体化治疗理念

Intracerebral haemorrhage: surgical therapy vs. patient-adapted treatment concept.

作者信息

Ruth Albert, Schulmeyer Frank Josef, Woertgen Chris, Brawanski Alexander

机构信息

Department of Neurosurgery, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.

出版信息

J Clin Neurosci. 2004 Apr;11(3):259-62. doi: 10.1016/S0967-5868(03)00154-1.

Abstract

In spontaneous intracerebral haemorrhage (SICH), the indication for surgery is still controversial. Therefore we developed clinical guidelines for therapy and compared the outcome of these patients to an exclusively surgically treated group. We retrospectively evaluated outcome in 70 patients with SICH, who were treated only surgically and compared this group with 58 prospectively collected patients, who were treated surgically (n=13) or medically (n=45). Initial level of consciousness, haematoma volume, and ventricular extension of blood were inversely correlated with mortality (p<0.0001, respectively). Use of clinical guidelines reduced the number of operations without affecting the outcome. We can formulate the following guidelines according to our data: comatose patients with and without brain herniation signs should be treated conservatively. Patients with a haematoma volume between 25 and 85 ml and a clinical deterioration are candidates for surgical therapy.

摘要

在自发性脑出血(SICH)中,手术指征仍存在争议。因此,我们制定了治疗临床指南,并将这些患者的治疗结果与单纯接受手术治疗的患者组进行比较。我们回顾性评估了70例仅接受手术治疗的SICH患者的治疗结果,并将该组与58例前瞻性收集的患者进行比较,后者接受手术治疗(n = 13)或药物治疗(n = 45)。初始意识水平、血肿体积和血液向脑室的扩展与死亡率呈负相关(分别为p < 0.0001)。使用临床指南减少了手术数量,同时不影响治疗结果。根据我们的数据,我们可以制定以下指南:有或无脑疝体征的昏迷患者应接受保守治疗。血肿体积在25至85毫升之间且临床症状恶化的患者是手术治疗的候选对象。

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