社会压力会改变急性泰勒氏病毒感染的严重程度。
Social stress alters the severity of acute Theiler's virus infection.
作者信息
Johnson R R, Storts R, Welsh T H, Welsh C J R, Meagher M W
机构信息
Department of Psychology, College of Liberal Arts, Texas A&M University, Mailstop 4328, College Station, TX 77843, USA.
出版信息
J Neuroimmunol. 2004 Mar;148(1-2):74-85. doi: 10.1016/j.jneuroim.2003.11.009.
Our laboratory has previously shown that restraint stress resulted in decreased Theiler's virus-induced CNS inflammation, while exacerbating illness behaviors during the acute phase of disease. In contrast, social disruption stress (SDR) applied prior to infection led to the development of glucocorticoid (GC) resistance, and these animals developed more severe disease course, with increased inflammation. However, when SDR was applied concurrent with infection, GC resistance fails to develop, disease course is less severe and inflammation was moderate. These results suggest that the effects of SDR on Theiler's virus infection are dependent upon the timing of SDR application in relation to infection.
我们实验室之前的研究表明，束缚应激会导致泰勒氏病毒诱导的中枢神经系统炎症减轻，同时在疾病急性期会加剧疾病行为。相比之下，在感染前施加的社会破坏应激（SDR）会导致糖皮质激素（GC）抵抗的产生，这些动物会发展出更严重的病程，炎症也会增加。然而，当SDR与感染同时施加时，不会产生GC抵抗，病程不那么严重，炎症也较为适度。这些结果表明，SDR对泰勒氏病毒感染的影响取决于SDR相对于感染的施加时间。
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