患重症肌无力的单卵双胞胎中的自身免疫性T细胞和B细胞库。
The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis.
作者信息
Kakoulidou M, Ahlberg R, Yi Q, Giscombe R, Pirskanen R, Lefvert A K
机构信息
Immunological Research Laboratory, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
出版信息
J Neuroimmunol. 2004 Mar;148(1-2):183-91. doi: 10.1016/j.jneuroim.2003.09.019.
Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.
对两对单卵双胞胎进行了研究，这两对双胞胎患重症肌无力（MG）超过30年，研究内容涉及针对疾病相关自身抗原、乙酰胆碱受体、一种独特型和一种抗独特型人单克隆抗体的T细胞和抗体反应性。健康双胞胎和患重症肌无力的双胞胎具有非常相似的自身抗体库。健康双胞胎和患重症肌无力的双胞胎的IgG组分在被动转移后降低小鼠体内游离乙酰胆碱受体含量的能力相同。与患重症肌无力的姐妹相比，健康双胞胎对乙酰胆碱受体的T细胞反应较低。
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