Théodore Christine
Institut Guatave-Roussy, Département de médecine, Villejuif, France.
Bull Cancer. 2004 Jan;91(1):69-74.
Hormonal deprivation has been used for more than 60 years in the treatment of advanced prostate cancer However, the optimal form of this therapy is still an enigma. This review discusses some of the current challenges in the hormonal management of prostate cancer, regarding complete androgen blockade, intermittent treatment and the question of whether early hormonal deprivation is superior to delayed therapy. The choice of hormone therapy for cancer of the prostate depends not only on the desired progression free survival and overall survival but also an the patient's quality of life and on the treatment toxicities and costs.
激素剥夺疗法用于治疗晚期前列腺癌已有60多年历史。然而，这种疗法的最佳形式仍是个谜。本文综述了前列腺癌激素治疗当前面临的一些挑战，涉及完全雄激素阻断、间歇性治疗以及早期激素剥夺是否优于延迟治疗的问题。前列腺癌激素治疗的选择不仅取决于预期的无进展生存期和总生存期，还取决于患者的生活质量、治疗毒性和费用。
