5种尼古丁系统的对比测试：初次使用及偏好情况
Comparative testing of 5 nicotine systems: initial use and preferences.
作者信息
Schneider Nina G, Olmstead Richard E, Nides Mitchell, Mody Freny Vaghaiwalla, Otte-Colquette Pamela, Doan Kim, Patel Shilpan
机构信息
Nicotine Dependence Research Unit, Greater Los Angeles Veterans Administration, West Los Angeles, CA 90073, USA.
出版信息
Am J Health Behav. 2004 Jan-Feb;28(1):72-86. doi: 10.5993/ajhb.28.1.8.
OBJECTIVE
To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41).
METHODS
Subjects used each medication on arising (1/2 day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences.
RESULTS
Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs.
CONCLUSION
Subjects had varied reactions to NRTs that may affect initiation of cessation.
目的
在一项交叉研究（n = 41）中测试对5种尼古丁治疗方法（尼古丁替代疗法：2毫克和4毫克口香糖、吸入器、鼻喷雾剂、片剂）的初始反应。
方法
受试者在起床时（半天）使用每种药物，并在每天下午恢复吸烟。受试者对治疗方法在使用、强化、戒断、渴望和偏好方面进行（单独）评分和（比较）排序。
结果
总体偏好：吸入器（49%）、4毫克口香糖（24%）、2毫克口香糖（10%）、2毫克片剂（10%）、鼻喷雾剂（7%）。总体结果与药物个体特征的评分和排序一致。
结论
受试者对尼古丁替代疗法有不同反应，这可能会影响戒烟的开始。
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