Zaharik Michelle L, Finlay B Brett
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Front Biosci. 2004 May 1;9:1035-42. doi: 10.2741/1317.
Fe2+ has traditionally been considered the most important divalent cation involved in host-pathogen interactions. However, recent research indicates a previously unappreciated role for transition metal divalent cations other than Fe2+ during infection. Recent studies have identified an absolute requirement for Mn2+ in bacterial pathogens that are Fe2+-independent, indicating an important role for Mn2+ in pathogenesis. Potential roles for Mn2+ in pathogenesis include effects on the detoxification of reactive oxygen intermediates (ROIs), as a cofactor for enzymes involved in intermediary metabolism and signal transduction, and as a stimulus for virulence gene regulation. This review focuses on how these possible roles for Mn2+ may affect bacterial pathogenesis and the outcome of an infection.
传统上，Fe2+被认为是参与宿主-病原体相互作用的最重要的二价阳离子。然而，最近的研究表明，除Fe2+外的其他过渡金属二价阳离子在感染过程中具有此前未被认识到的作用。最近的研究已经确定，在不依赖Fe2+的细菌病原体中，Mn2+是绝对必需的，这表明Mn2+在发病机制中具有重要作用。Mn2+在发病机制中的潜在作用包括对活性氧中间体（ROIs）解毒的影响、作为参与中间代谢和信号转导的酶的辅助因子，以及作为毒力基因调控的刺激因素。本综述重点关注Mn2+的这些可能作用如何影响细菌发病机制和感染结果。
