细胞色素P450在肿瘤组织中的表达及其与癌症发展的关联。
Expression of cytochrome P450 in tumor tissues and its association with cancer development.
作者信息
Oyama Tsunehiro, Kagawa Norio, Kunugita Naoki, Kitagawa Kyoko, Ogawa Masanori, Yamaguchi Tetsunosuke, Suzuki Rie, Kinaga Tsuyoshi, Yashima Yasunori, Ozaki Shinichi, Isse Toyohi, Kim Yong-Dae, Kim Heon, Kawamoto Toshihiro
机构信息
Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
出版信息
Front Biosci. 2004 May 1;9:1967-76. doi: 10.2741/1378.
CYPs (cytochrome P450s) catalyze the conversion of numerous numbers of xenobiotics including carcinogens and drugs. CYPs can be involved in metabolic pathways of activation of procarcinogens and/or inactivation of carcinogens during the tumorigenic processes. Recently, increasing number of cancer tissues as well as normal tissues have been found to express a variety of CYPs. The local expression of CYPs in tumors appears to be very important for the management of cancers since CYPs expressed in tumors may be involved in activation and/or inactivation of anticancer drugs. The expression of CYPs in tumors may also convert endogenous substrates to metabolites that facilitate cancer development. In this review, we summarize the association of CYP expression in cancer tissues with carcinogenesis and cancer treatment.
细胞色素P450（CYPs）催化包括致癌物和药物在内的大量外源性物质的转化。在致癌过程中，CYPs可能参与前致癌物的激活和/或致癌物的失活代谢途径。最近，人们发现越来越多的癌组织以及正常组织都表达多种CYPs。肿瘤中CYPs的局部表达对于癌症的治疗似乎非常重要，因为肿瘤中表达的CYPs可能参与抗癌药物的激活和/或失活。肿瘤中CYPs的表达还可能将内源性底物转化为促进癌症发展的代谢产物。在本综述中，我们总结了癌组织中CYPs表达与致癌作用和癌症治疗的关系。
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