Cantani A
Service d'Allergologie et d'Immunologie Clinique, Université de Roma La Sapienza.
Allerg Immunol (Paris). 1992 Jun;24(6):199-205.
Over the last few years food allergies have become a clinical problem of prime importance in children. It is clear that food allergy is most frequent in infants. Food macromolecules are absorbed at every age, but most evidently during the first months of life. Many facts show that the barrier of the gastro-intestinal tract against harmful agents present in the intestinal lumen is not completely developed in infants and especially in newborns. Deficiencies in the secretory system for TgA contribute to greater permeability of the intestine for allergenic macromolecules in early childhood.
在过去几年里,食物过敏已成为儿童中极为重要的临床问题。显然,食物过敏在婴儿中最为常见。食物大分子在各个年龄段都会被吸收,但在生命的最初几个月最为明显。许多事实表明,婴儿尤其是新生儿的胃肠道对肠腔内有害物质的屏障尚未完全发育。分泌型TgA系统的缺陷导致幼儿期肠道对变应原性大分子的通透性增加。