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[儿童消化系统中的局部免疫现象与食物过敏]

[Local immunological phenomena in the digestive system of the child and food allergy].

作者信息

Cantani A

机构信息

Service d'Allergologie et d'Immunologie Clinique, Université de Roma La Sapienza.

出版信息

Allerg Immunol (Paris). 1992 Jun;24(6):199-205.

PMID:1497795
Abstract

Over the last few years food allergies have become a clinical problem of prime importance in children. It is clear that food allergy is most frequent in infants. Food macromolecules are absorbed at every age, but most evidently during the first months of life. Many facts show that the barrier of the gastro-intestinal tract against harmful agents present in the intestinal lumen is not completely developed in infants and especially in newborns. Deficiencies in the secretory system for TgA contribute to greater permeability of the intestine for allergenic macromolecules in early childhood.

摘要

在过去几年里,食物过敏已成为儿童中极为重要的临床问题。显然,食物过敏在婴儿中最为常见。食物大分子在各个年龄段都会被吸收,但在生命的最初几个月最为明显。许多事实表明,婴儿尤其是新生儿的胃肠道对肠腔内有害物质的屏障尚未完全发育。分泌型TgA系统的缺陷导致幼儿期肠道对变应原性大分子的通透性增加。

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