犬吉氏巴贝斯虫表面抗原P50抗血清对给予犬红细胞的严重联合免疫缺陷小鼠体内寄生虫生长的抑制作用
Inhibitory effect of antiserum to surface antigen P50 of Babesia gibsoni on growth of parasites in severe combined immunodeficiency mice given canine red blood cells.
作者信息
Fukumoto Shinya, Xuan Xuenan, Takabatake Noriyuki, Igarashi Ikuo, Sugimoto Chihiro, Fujisaki Kozo, Nagasawa Hideyuki, Mikami Takeshi, Suzuki Hiroshi
机构信息
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
出版信息
Infect Immun. 2004 Mar;72(3):1795-8. doi: 10.1128/IAI.72.3.1795-1798.2004.
Abstract
The inhibitory effect of an antiserum to surface protein P50 of Babesia gibsoni on the growth of the parasite was determined with severe combined immunodeficiency mice given canine red blood cells. The antiserum to the recombinant P50 protein significantly inhibited the parasite growth, indicating that P50 might be a useful vaccine candidate.
摘要
用给予犬红细胞的严重联合免疫缺陷小鼠，测定了抗吉氏巴贝斯虫表面蛋白P50抗血清对该寄生虫生长的抑制作用。重组P50蛋白的抗血清显著抑制了寄生虫的生长，表明P50可能是一种有用的疫苗候选物。
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本文引用的文献
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