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犬吉氏巴贝斯虫表面抗原P50抗血清对给予犬红细胞的严重联合免疫缺陷小鼠体内寄生虫生长的抑制作用

Inhibitory effect of antiserum to surface antigen P50 of Babesia gibsoni on growth of parasites in severe combined immunodeficiency mice given canine red blood cells.

作者信息

Fukumoto Shinya, Xuan Xuenan, Takabatake Noriyuki, Igarashi Ikuo, Sugimoto Chihiro, Fujisaki Kozo, Nagasawa Hideyuki, Mikami Takeshi, Suzuki Hiroshi

机构信息

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

出版信息

Infect Immun. 2004 Mar;72(3):1795-8. doi: 10.1128/IAI.72.3.1795-1798.2004.

DOI:10.1128/IAI.72.3.1795-1798.2004
PMID:14977989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356003/
Abstract

The inhibitory effect of an antiserum to surface protein P50 of Babesia gibsoni on the growth of the parasite was determined with severe combined immunodeficiency mice given canine red blood cells. The antiserum to the recombinant P50 protein significantly inhibited the parasite growth, indicating that P50 might be a useful vaccine candidate.

摘要

用给予犬红细胞的严重联合免疫缺陷小鼠，测定了抗吉氏巴贝斯虫表面蛋白P50抗血清对该寄生虫生长的抑制作用。重组P50蛋白的抗血清显著抑制了寄生虫的生长，表明P50可能是一种有用的疫苗候选物。

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Inhibitory effect of antiserum to surface antigen P50 of Babesia gibsoni on growth of parasites in severe combined immunodeficiency mice given canine red blood cells.犬吉氏巴贝斯虫表面抗原P50抗血清对给予犬红细胞的严重联合免疫缺陷小鼠体内寄生虫生长的抑制作用
Infect Immun. 2004 Mar;72(3):1795-8. doi: 10.1128/IAI.72.3.1795-1798.2004.
2
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Clin Diagn Lab Immunol. 2005 Apr;12(4):557-9. doi: 10.1128/CDLI.12.4.557-559.2005.

本文引用的文献

1
High-level expression of truncated surface antigen P50 of Babesia gibsoni in insect cells by baculovirus and evaluation of its immunogenicity and antigenicity.通过杆状病毒在昆虫细胞中高效表达吉氏巴贝斯虫截短表面抗原P50及其免疫原性和抗原性评估
Clin Diagn Lab Immunol. 2003 Jul;10(4):596-601. doi: 10.1128/cdli.10.4.596-601.2003.
2
Continuous in vitro culture of erythrocytic stages of Babesia gibsoni and virulence of the cultivated parasite.吉氏巴贝斯虫红细胞内期的体外连续培养及培养寄生虫的毒力
J Vet Med Sci. 2002 Jul;64(7):571-5. doi: 10.1292/jvms.64.571.
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Clinical and hematologic effects of experimental infection of dogs with recently identified Babesia gibsoni-like isolates from Oklahoma.
J Am Vet Med Assoc. 2002 Jan 15;220(2):185-9. doi: 10.2460/javma.2002.220.185.
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Babesia gibsoni infection in a dog from indiana.一只来自印第安纳州的狗感染了吉氏巴贝斯虫。
Vet Clin Pathol. 2001;30(4):180-188. doi: 10.1111/j.1939-165x.2001.tb00429.x.
5
Babesia gibsoni infection among dogs in the southeastern United States.美国东南部犬类中的吉氏巴贝斯虫感染。
J Am Vet Med Assoc. 2002 Feb 1;220(3):325-9. doi: 10.2460/javma.2002.220.325.
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Fatal Babesia gibsoni infection in a dog from Spain.西班牙一只犬的吉氏巴贝斯虫致命感染
Vet Rec. 2001 Jun 30;148(26):819-20. doi: 10.1136/vr.148.26.819.
7
Identification and expression of a 50-kilodalton surface antigen of Babesia gibsoni and evaluation of its diagnostic potential in an enzyme-linked immunosorbent assay.吉氏巴贝斯虫50千道尔顿表面抗原的鉴定与表达及其在酶联免疫吸附测定中的诊断潜力评估
J Clin Microbiol. 2001 Jul;39(7):2603-9. doi: 10.1128/JCM.39.7.2603-2609.2001.
8
Morphological changes of Babesia gibsoni grown in canine red blood cell-substituted severe combined immune deficiency mice.在犬红细胞替代的严重联合免疫缺陷小鼠中生长的吉氏巴贝斯虫的形态学变化。
J Parasitol. 2000 Oct;86(5):956-8. doi: 10.1645/0022-3395(2000)086[0956:MCOBGG]2.0.CO;2.
9
Canine piroplasmosis due to Babesia gibsoni: clinical and morphological aspects.
Vet Rec. 1998 Feb 14;142(7):168-9. doi: 10.1136/vr.142.7.168.
10
Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris).家犬（犬属）吉氏巴贝斯虫感染的临床、解剖学和免疫病理学特征
J Parasitol. 1997 Aug;83(4):692-9.