Zingarelli G, Ellman G, Hom A, Wymore M, Heidorn S, Chicz-DeMet A
Sonoma Developmental Center, Eldridge, CA 95431.
Am J Ment Retard. 1992 Jul;97(1):57-63.
Eight young adults who were diagnosed with autism were given the opiate antagonist naltrexone to control self-injurious behavior and maladaptive idiosyncratic mannerisms. The drug and placebo were administered in a double-blind crossover design over 17 weeks. Although one subject appeared to have partial decreases in maladaptive behaviors associated with naltrexone use, the drugs, as administered in this study, did not reduce the self-injurious and other maladaptive behaviors of the subjects.
八名被诊断患有自闭症的年轻人服用了阿片类拮抗剂纳曲酮，以控制自伤行为和适应不良的特殊癖好。药物和安慰剂以双盲交叉设计给药，持续17周。尽管有一名受试者使用纳曲酮后适应不良行为似乎有部分减少，但本研究中所使用的药物并未减少受试者的自伤行为和其他适应不良行为。
