脆性X综合征和自闭症的环磷酸腺苷表型
The cyclic AMP phenotype of fragile X and autism.
作者信息
Kelley Daniel J, Bhattacharyya Anita, Lahvis Garet P, Yin Jerry C P, Malter Jim, Davidson Richard J
机构信息
Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin, Madison, WI, USA.
出版信息
Neurosci Biobehav Rev. 2008 Oct;32(8):1533-43. doi: 10.1016/j.neubiorev.2008.06.005. Epub 2008 Jun 17.
Abstract
Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.
摘要
环磷酸腺苷（cAMP）是一种第二信使，参与包括记忆处理和焦虑在内的许多过程。脆性X综合征（FX）是智力障碍和自闭症最常见的遗传性病因，其表型表现为记忆缺陷和焦虑。在此，我们综述了有关FX和自闭症中cAMP级联功能改变的报道观察结果。环磷酸腺苷是一种潜在有用的生化标志物，可用于区分与FX共病的自闭症和自闭症本身，并且cAMP级联可能是FX和自闭症的一个可行治疗靶点。
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