光和氧对新制癌菌素稳定性及DNA切割活性的影响。
Effect of light and oxygen on neocarzinostatin stability and DNA-cleaving activity.
作者信息
Burger R M, Peisach J, Horwitz S B
出版信息
J Biol Chem. 1978 Jul 25;253(14):4830-2.
PMID:149790
Abstract
The in vitro DNA-cleaving activity of neocarzinostatin, a protein antibiotic, is strongly but reversibly inhibited by anaerobiosis. Half-maximal activity is seen in the presence of 0.25 mM O2. The stability of neocarzinostatin, as demonstrated by its ability to cleave DNA, is significantly reduced in light. Inactivation by light is complete and irreversible.
摘要
蛋白抗生素新制癌菌素的体外DNA切割活性受到厌氧作用的强烈但可逆的抑制。在0.25 mM氧气存在的情况下可观察到半数最大活性。新制癌菌素切割DNA的能力表明，其稳定性在光照下显著降低。光照导致的失活是完全且不可逆的。
Zotero 插件