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介入放射学在结直肠癌肝转移治疗中的贡献(术前门静脉栓塞——经皮射频消融)

[Contribution of interventional radiology to the treatment of liver metastases of colorectal cancers (pre-operative portal embolization--percutaneous radiofrequency)].

作者信息

de Baere Thierry

机构信息

Service de radiologie interventionnelle, Institut Gustave Roussy-39 rue Camille Demoulins-94805 Villejuif.

出版信息

Bull Acad Natl Med. 2003;187(5):835-44; discussion 844-5.

Abstract

Selective embolization of portal branches of some liver segments will induce hypertrophy of non embolized segments of the liver. This induced hypertrophy allows us to perform hepatectomy in patients with initially insufficient volume of future remnant liver (FRL). This technique aims at patients with initial FRL volume below 25% of total liver volume, and patient with initial FRL volume below 40% of total liver volume when a diffuse liver disease is present. The mean hypertrophy obtained 1 month after pre-operative portal vein embolization (POPE) was 82 +/- 56% in our experience. Post-operative complications and long-term survival for patient operating after POPE is not different from patient operated with a classical hepatectomy. Radiofrequency is able to destroy hepatic tumors after insertion of a needle electrode inside the tumor under imaging guidance. Thermocoagulation of the targeted tissue is obtained after emission of a 400 to 500 KHz alternative able to induce frictional heating in the neighboring of the electrode. Spreading of this technique is at least partially explained by a relative high local efficacy (90% of small tumor targeted can be destroyed) and a low invasiveness. However, today no benefit in survival has been demonstrated for patients treated with radiofrequency ablation of liver tumors. Consequently, this technique should not be proposed for tumors that can be surgically resected.

摘要

对肝脏某些肝段的门静脉分支进行选择性栓塞,会导致未栓塞肝段的肥大。这种诱导性肥大使我们能够对初始未来残余肝(FRL)体积不足的患者进行肝切除术。该技术针对初始FRL体积低于全肝体积25%的患者,以及存在弥漫性肝病时初始FRL体积低于全肝体积40%的患者。根据我们的经验,术前门静脉栓塞(POPE)1个月后获得的平均肥大率为82±56%。接受POPE后手术的患者的术后并发症和长期生存率与接受经典肝切除术的患者并无差异。在成像引导下将针状电极插入肿瘤内后,射频能够破坏肝肿瘤。在发射400至500千赫的交流电后,可在电极附近诱导摩擦热,从而实现对目标组织的热凝。该技术的广泛应用至少部分归因于其相对较高的局部疗效(90%的靶向小肿瘤可被破坏)和低侵袭性。然而,目前尚未证明对肝肿瘤进行射频消融治疗的患者在生存率方面有获益。因此,对于可手术切除的肿瘤,不应采用该技术。

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