实验性诱导外分泌性胰腺功能不全犬的肝脏生化及组织病理学 findings（这里“findings”可能是指“结果”之类的意思，原词翻译为“发现”稍显生硬，结合语境推测为更合适的表达）
Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency.
作者信息
Adamama-Moraitou K K, Rallis T S, Papazoglou L G, Papasteriadis A, Roubies N, Kaldrimidou H, Leontides L S
机构信息
Department of Clinical Studies School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St. Voutyra Street, 54627 Thessaloniki, Greece.
出版信息
Can J Vet Res. 2004 Jan;68(1):56-61.
Routine liver biochemical parameters were evaluated in 8 dogs with exocrine pancreatic insufficiency (EPI) induced by surgical ligation of the pancreatic duct and the pancreatic branch of the pancreaticoduodenal artery and confirmed with the trypsin-like immunoreactivity test. Eight additional dogs were used as healthy controls. Data collection began at the 4th week postoperatively and continued weekly to the 21st week. In the dogs with EPI, the serum activity of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were consistently elevated. The serum total and conjugated bilirubin concentrations remained within normal limits throughout the experimental period. Histopathological study revealed hepatic lipidosis in the dogs with EPI. Therefore, since this condition seems to be an additional consequence of EPI in dogs, laboratory evaluation of dogs with EPI must include assessment of liver function, to determine if additional or different therapeutic measures are indicated.
对8只通过手术结扎胰管和胰十二指肠动脉的胰腺分支诱导出外分泌性胰腺功能不全（EPI）的犬进行了常规肝脏生化参数评估，并通过类胰蛋白酶免疫反应性试验进行了确认。另外8只犬用作健康对照。数据收集从术后第4周开始，每周持续进行至第21周。在患有EPI的犬中，丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶的血清活性持续升高。在整个实验期间，血清总胆红素和结合胆红素浓度均保持在正常范围内。组织病理学研究显示患有EPI的犬出现肝脏脂肪变性。因此，由于这种情况似乎是犬EPI的另一个后果，对患有EPI的犬进行实验室评估必须包括肝功能评估，以确定是否需要采取额外的或不同的治疗措施。
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