Hsu Hsiang-Hao, Huang Chiu-Ching
Department of Nephrology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.
Int J Hematol. 2004 Jan;79(1):48-51. doi: 10.1007/BF02983533.
Acute spontaneous tumor lysis (ASTL) syndrome, an extremely rare disease, requires prompt recognition and aggressive management because it is fulminant at its outset, associated with severe metabolic derangement, and potentially reversible. We describe an unusual case in which spontaneous tumor lysis occurred in anaplastic large T-cell lymphoma associated with acute uric acid nephropathy, persistent oliguria, and shock. This case contrasts markedly with previously reported cases of ASTL syndrome, which developed mainly in the pathologic type of Burkitt lymphoma. To our knowledge, this is the first reported occurrence of ASTL syndrome associated with anaplastic large T-cell type lymphoma. This report also chronicles our successful experience with continuous renal replacement therapy in the presence of compromised hemodynamic status.
急性自发性肿瘤溶解（ASTL）综合征是一种极为罕见的疾病，因其起病急骤、伴有严重的代谢紊乱且具有潜在可逆性，所以需要迅速识别并积极处理。我们描述了一例罕见病例，该病例为间变性大T细胞淋巴瘤发生自发性肿瘤溶解，并伴有急性尿酸肾病、持续性少尿和休克。此病例与先前报道的主要发生于伯基特淋巴瘤病理类型的ASTL综合征病例明显不同。据我们所知，这是首次报道的与间变性大T细胞型淋巴瘤相关的ASTL综合征病例。本报告还记录了我们在血流动力学状态受损情况下进行连续性肾脏替代治疗的成功经验。
