Ueda Chiyoko, Nishikori Momoko, Kitawaki Toshio, Uchiyama Takashi, Ohno Hitoshi
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Int J Hematol. 2004 Jan;79(1):52-4. doi: 10.1007/BF02983534.
We present a patient with stage III de novo diffuse large B-cell lymphoma. The lymphoma cells showed mature B-cell immunophenotype but lacked surface immunoglobulin (Ig) expression. Long-distance and long-distance inverse polymerase chain reaction assays to detect the oncogene/Ig gene rearrangement revealed that the cells carried 3 independent fusion genes, namely, c-MYC/Ig heavy chain gene (IgH), BCL2/IgH, and Ig lambda light chain gene/BCL6. Thus, the lymphoma cells concurrently carried t(8;14)(q24;q32), t(14;18)(q32;q21), and t(3;22)(q27;q11), which developed in association with class switching, V/D/J recombination, and somatic hypermutation, respectively. The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome.
我们报告了一名患有Ⅲ期原发性弥漫性大B细胞淋巴瘤的患者。淋巴瘤细胞显示成熟B细胞免疫表型，但缺乏表面免疫球蛋白（Ig）表达。检测癌基因/I g基因重排的长距离和长距离反向聚合酶链反应分析显示，这些细胞携带3个独立的融合基因，即c-MYC/I g重链基因（IgH）、BCL2/I gH和I gλ轻链基因/BCL6。因此，淋巴瘤细胞同时携带t(8;14)(q24;q32)、t(14;18)(q32;q21)和t(3;22)(q27;q11)，它们分别与类别转换、V/D/J重排和体细胞超突变相关。该淋巴瘤对放化疗有反应，患者已健康存活2年，提示多个癌基因重排不一定与不良临床结局相关。
