Huff Nicole C, Rudy Jerry W
Department of Psychology, University of Colorado, Boulder, CO 80309, USA.
Behav Neurosci. 2004 Feb;118(1):53-62. doi: 10.1037/0735-7044.118.1.53.
Preexposing rats to the context facilitates subsequent contextual fear conditioning. This effect depends on the hippocampus (J. W. Rudy, R. M. Barrientos, & R. C. O'Reilly, 2002). The authors report that inactivating the basolateral region of the amygdala (BLA) by injecting muscimol, a GABAA agonist, before or after preexposure reduced this effect. In contrast, bilateral injections of anisomycin, a protein synthesis inhibitor, into BLA did not impair the consolidation of the context memory. However, when injected after fear conditioning, anisomycin impaired consolidation of both contextual and auditory-cue fear conditioning. Results are consistent with 2 ideas about the amygdala's contribution to memory: (a) It modulates memory formation in other regions of the brain, and (b) it is a storage site for cue-shock associations.
预先将大鼠暴露于环境中有助于随后的情境恐惧条件反射。这种效应依赖于海马体（J. W. 鲁迪、R. M. 巴里恩托斯和R. C. 奥赖利，2002年）。作者报告称，在预先暴露之前或之后，通过注射GABAA激动剂蝇蕈醇使杏仁核基底外侧区域（BLA）失活，会降低这种效应。相比之下，向BLA双侧注射蛋白质合成抑制剂茴香霉素并不损害情境记忆的巩固。然而，在恐惧条件反射后注射时，茴香霉素会损害情境和听觉线索恐惧条件反射的巩固。结果与关于杏仁核对记忆的贡献的两种观点一致：（a）它调节大脑其他区域的记忆形成，（b）它是线索 - 电击关联的存储位点。
