Lee Adrian V, Chamness Gary, Oesterreich Steffi
Breast Center, Baylor College of Medicine and the Methodist Hospital, Houston, Texas, USA.
Breast Cancer Res. 2004 Jan 19;6(2):E10. doi: 10.1186/bcr758.
The San Antonio Breast Cancer Symposium is the largest annual meeting devoted solely to breast cancer research. The late William L McGuire's vision for this meeting was to stimulate 'translational research', many years before this term became popular. In this way, the San Antonio Breast Cancer Symposium represents a forum in which basic and clinical researchers present their research side by side. Each year sees the continued evolution of our understanding of the basic mechanisms of breast cancer initiation and progression, and the clinical application of this knowledge. Major topics of discussion at the symposium this year were the cell cycle, new evolving concepts of estrogen receptor action, breast cancer stem cells, new predictive and prognostic markers (including microarray studies), and continued exploration of the mechanisms of drug resistance. This report will summarize preclinical and translational highlights from the meeting.
圣安东尼奥乳腺癌研讨会是唯一专注于乳腺癌研究的年度盛会。已故的威廉·L·麦圭尔对此次会议的愿景是推动“转化研究”，这一理念早在该术语流行之前就已提出。通过这种方式，圣安东尼奥乳腺癌研讨会成为了一个基础研究人员和临床研究人员并肩展示研究成果的平台。每年，我们对乳腺癌发生和发展的基本机制的理解以及这些知识的临床应用都在不断演进。今年研讨会的主要讨论主题包括细胞周期、雌激素受体作用的新发展概念、乳腺癌干细胞、新的预测和预后标志物（包括微阵列研究）以及对耐药机制的持续探索。本报告将总结此次会议的临床前和转化研究亮点。
