Dorsch M M, Otto K, Hedrich H J
Institute for Laboratory Animal Science, Medical School Hanover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
Lab Anim. 2004 Jan;38(1):44-9. doi: 10.1258/00236770460734380.
Thirty-two female mice used for embryo transfer or as controls received either metamizol or equal volumes of normal saline administered subcutaneously following induction of anaesthesia with ketamine-xylazine. Body weight was measured immediately before surgery, after 24 and after 48 h. The duration of the surgical anaesthesia was recorded and postoperative behavioural responses were measured. Comparison of the treatment groups revealed no significant differences in body weight and recovery times, nor were other signs of discomfort detected in either treatment group. It was concluded that administration of metamizol did not provide additional analgesia following embryo transfer in mice anaesthetized with ketamine-xylazine.
32只用于胚胎移植或作为对照的雌性小鼠，在用氯胺酮-赛拉嗪诱导麻醉后，皮下注射了安乃近或等量的生理盐水。在手术前、术后24小时和48小时测量体重。记录手术麻醉的持续时间，并测量术后行为反应。治疗组之间的比较显示，体重和恢复时间没有显著差异，两个治疗组也未检测到其他不适迹象。得出的结论是，在用氯胺酮-赛拉嗪麻醉的小鼠中，胚胎移植后给予安乃近并未提供额外的镇痛效果。
