Anibarro Luis, Lires José Antonio, Iglesias Fernando, Vilariño Carlos, Baloria Adolfo, de Lis José María, Ojea Rafael
Unidad de Tuberculose y Enfermedades Infecciosas, Servicio de Medicina Interna, Complexo Hospitalario de Pontevedra, Spain.
Gac Sanit. 2004 Jan-Feb;18(1):38-44. doi: 10.1016/s0213-9111(04)71997-4.
To determine the prevalence and characteristics of social risk factors (SRF) for noncompliance with treatment in patients with tuberculosis (TB) in Pontevedra.
We performed a descriptive analysis of patients with TB and SRF diagnosed between 1996 and 2002. A patient was considered as having SRF if he or she was socially isolated (alcoholism, intravenous drug use, prison inmate, homelessness or social maladjustment) or was an immigrant. The prevalence, annual trend of SRF and patient outcomes were calculated. The influence of direct observation of treatment administration on the outcome of patients with SRF was also analyzed.
Of 775 patients with TB, 156 (20.1%) had at least one SRF. Eighty-six patients were alcoholic, 41 were intravenous drug users, 24 were immigrants, 11 were homeless, 11 showed social maladjustment and 10 were prison inmates. The presence of SRF among TB patients showed no tendency to increase or decrease during the study period, except for the increasing number of immigrants (chi 2 for lineal tendency = 12.24; p = 0.005). Final outcomes were significantly better in patients without SRF (90.4 vs 70.8% of satisfactory final outcomes; p < 0.001). Direct observation of treatment did not increase satisfactory outcomes in patients with SRF.
Patients with TB and SRF have a significantly higher proportion of unsatisfactory final outcomes. The presence of SRF is relatively low in our environment. The number of immigrants from countries with a high prevalence of TB shows an incipient tendency to increase. This finding should be taken into account to achieve better control of the disease.
确定庞特维德拉地区结核病患者治疗不依从的社会风险因素(SRF)的患病率及特征。
我们对1996年至2002年间诊断出患有结核病和SRF的患者进行了描述性分析。如果患者存在社会孤立情况(酗酒、静脉吸毒、囚犯、无家可归或社会适应不良)或为移民,则被视为患有SRF。计算了SRF的患病率、年度趋势及患者结局。还分析了直接观察治疗给药对SRF患者结局的影响。
在775例结核病患者中,156例(20.1%)至少有一项SRF。86例患者酗酒,41例静脉吸毒,24例为移民,11例无家可归,11例表现出社会适应不良,10例为囚犯。除移民数量增加外(线性趋势的卡方值=12.24;p=0.005),研究期间结核病患者中SRF的存在无增加或减少趋势。无SRF的患者最终结局明显更好(满意的最终结局分别为90.4%和70.8%;p<0.001)。直接观察治疗并未提高SRF患者的满意结局。
患有结核病和SRF的患者最终结局不满意的比例显著更高。在我们的环境中,SRF的存在相对较低。来自结核病高流行国家的移民数量呈初步增加趋势。为更好地控制该疾病,应考虑这一发现。