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肿瘤坏死因子：一种细胞凋亡的“杂耍者”？

Tumor necrosis factor: an apoptosis JuNKie?

作者信息

Varfolomeev Eugene E, Ashkenazi Avi

机构信息

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

出版信息

Cell. 2004 Feb 20;116(4):491-7. doi: 10.1016/s0092-8674(04)00166-7.

DOI:10.1016/s0092-8674(04)00166-7
PMID:14980217
Abstract

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

摘要

肿瘤坏死因子（TNF）的主要功能是通过IKK/NFκB和JNK/AP-1信号级联反应开启基因转录来刺激炎症反应。TNF还可通过半胱天冬酶-8触发细胞凋亡，但其这一活性的作用及潜在机制尚未完全明确。在此，我们综述了关于JNK在调节TNF依赖性细胞凋亡中作用的最新数据，并讨论了目前已知的细胞如何决定对TNF作出存活或死亡反应的情况。

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Tumor necrosis factor: an apoptosis JuNKie?肿瘤坏死因子：一种细胞凋亡的“杂耍者”？
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