Tamura S, Morikawa Y, Iwanishi H, Hisaoka T, Senba E
Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
Neuroscience. 2004;124(2):261-7. doi: 10.1016/j.neuroscience.2003.11.036.
The developmental processes of maturation in the CNS are the result of specific events including mitogenesis, differentiation, and cell death which occur in a precise spatial and temporal manner. It has been reported that many transcription factors, including forkhead transcription factors, play a key role in these processes. First, we examined the expression pattern of the forkhead transcription factor Foxp1 in the adult CNS. Foxp1 was highly expressed in the striatum and moderately in the cerebral cortex, CA1/2 subfields of the hippocampus, and several thalamic nuclei. In situ hybridization combined with immunohistochemistry in the striatum of adult mice revealed that Foxp1 mRNA was detected in a subset of projection neurons, not in interneurons. In addition, the expression of Foxp1 mRNA was observed in the developing basal ganglia with the exception of the globus pallidus. Thus, Foxp1 mRNA was expressed in a subset of striatal projection neurons, probably the matrix neurons. The expression pattern of Foxp1 mRNA suggests that Foxp1 may play a role in the development and formation of a circuit in the basal ganglia, which is involving the matrix neurons.
中枢神经系统（CNS）中的成熟发育过程是特定事件的结果，这些事件包括有丝分裂、分化和细胞死亡，它们以精确的空间和时间方式发生。据报道，许多转录因子，包括叉头转录因子，在这些过程中起关键作用。首先，我们研究了叉头转录因子Foxp1在成体中枢神经系统中的表达模式。Foxp1在纹状体中高表达，在大脑皮层、海马体的CA1/2亚区和几个丘脑核中中等表达。成年小鼠纹状体中的原位杂交结合免疫组织化学显示，在投射神经元的一个子集中检测到Foxp1 mRNA，而在中间神经元中未检测到。此外，除苍白球外，在发育中的基底神经节中观察到Foxp1 mRNA的表达。因此，Foxp1 mRNA在纹状体投射神经元的一个子集中表达，可能是基质神经元。Foxp1 mRNA的表达模式表明，Foxp1可能在基底神经节中涉及基质神经元的回路的发育和形成中发挥作用。
