Phan K Luan, Taylor Stephan F, Welsh Robert C, Ho Shao-Hsuan, Britton Jennifer C, Liberzon Israel
Department of Psychiatry and Behvioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Neuroimage. 2004 Feb;21(2):768-80. doi: 10.1016/j.neuroimage.2003.09.072.
Accurate appraisal of meaningful environmental signals involves the interpretation of salient information for their intrinsic emotional value and personal relevance. We examined the neural basis for these components of endogenous salience during such appraisals using trial-related functional magnetic resonance imaging (fMRI). Subjects viewed affective pictures and assessed either the emotional intensity or extent of self-relatedness of the content of those pictures. In a parametric factorial design, individualized subjective ratings of these two dimensions were correlated with brain activity. The nucleus accumbens (NAcc) responded to both increasing emotional intensity and self-relatedness. Activity in the amygdala was specifically related to affective judgments and emotional intensity. The volitional act of appraising the extent of personal association specifically engaged the ventral medial prefrontal cortex (MPFC), and additionally recruited dorsal medial frontal regions and insula as the extent of self-relatedness increased. The findings highlight both overlapping and segregated neural representations of intrinsic value and personal relevance during the appraisal of emotional stimuli.
对有意义的环境信号进行准确评估，需要对显著信息的内在情感价值和个人相关性进行解读。我们使用与试验相关的功能磁共振成像（fMRI），研究了在这种评估过程中内源性显著性这些成分的神经基础。受试者观看情感图片，并评估这些图片内容的情感强度或与自我相关性的程度。在参数化析因设计中，这两个维度的个性化主观评分与大脑活动相关。伏隔核（NAcc）对情感强度和自我相关性的增加均有反应。杏仁核的活动与情感判断和情感强度特别相关。评估个人关联程度的意志行为特别激活了腹内侧前额叶皮层（MPFC），并且随着自我相关性程度的增加，还额外激活了背内侧额叶区域和脑岛。这些发现突出了在情感刺激评估过程中，内在价值和个人相关性在神经表征上的重叠和分离。
