Potent imidazole and triazole CB1 receptor antagonists related to SR141716.
作者信息
Dyck Brian, Goodfellow Val S, Phillips Teresa, Grey Jonathan, Haddach Mustapha, Rowbottom Martin, Naeve Gregory S, Brown Brock, Saunders John
机构信息
Departments of Medicinal Chemistry, Pharmacology and Molecular Biology, Neurocrine Biosciences Inc., 10555 Science Center Drive, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1151-4. doi: 10.1016/j.bmcl.2003.12.068.
PMID:14980654
Abstract
Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB(1) receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analogous triazoles are less so due to the absence of an additional substituent on the azole ring.
摘要
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