新的呋喃木糖醇和肌醇低聚物。作为糖苷酶抑制剂的合成及生物学评价。
New oligomers of conduritol-F and muco-inositol. Synthesis and biological evaluation as glycosidase inhibitors.
作者信息
Freeman Stanley, Hudlicky Tomas
机构信息
Department of Chemistry, University of Florida, PO Box 117200, Gainesville, FL 32611, USA.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1209-12. doi: 10.1016/j.bmcl.2003.12.050.
PMID:14980667
Abstract
Several oligomers possessing the configuration of conduritol-F and muco-inositol have been prepared and tested against six glycosidase enzymes. Electrochemical dehalogenation and reductive deprotection of cinnamyl ethers are featured in the reported syntheses. The synthesis, properties, and biological activities are investigated.
摘要
已经制备了几种具有康杜醇-F和粘质肌醇构型的低聚物，并针对六种糖苷酶进行了测试。所报道的合成方法的特点是肉桂基醚的电化学脱卤和还原脱保护。对其合成、性质和生物活性进行了研究。
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