7-二烷基氨甲基苯并[g]喹喔啉-5,10-二酮的合成与体外评价
Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones.
作者信息
Lee Heesoon, Cho Sungmoon, Namgoong Kwon, Jung Jae-Kyung, Cho Jungsook, Yang Sung-Il
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1235-7. doi: 10.1016/j.bmcl.2003.12.046.
PMID:14980672
Abstract
A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line.
摘要
合成了一系列带有7-二烷基氨基甲基取代基的苯并[g]喹喔啉-5,10-二酮衍生物，并评估了它们对四种人类癌细胞系（HCT-15、SK-OV-3、MD-MB-468和T-47D）的体外细胞毒性活性。活性最高的化合物9d对HCT-15癌细胞系显示出与阿霉素相当的细胞毒性活性。
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