Vaux D L, Aguila H L, Weissman I L
Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305.
Int Immunol. 1992 Jul;4(7):821-4. doi: 10.1093/intimm/4.7.821.
'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded into nucleosome-sized fragments. Therefore the early steps in apoptosis induced by factor deprivation differ from those triggered by cytotoxic T cells, although they share a common final pathway featuring degradation of the DNA and loss of cytoplasmic membrane integrity.
“程序性细胞死亡”已被用于描述被细胞毒性T细胞杀死或因生长因子剥夺而死亡的细胞。尽管bcl-2可以防止因生长因子剥夺而死亡的细胞死亡，但它未能保护细胞免受T细胞杀伤。尽管有bcl-2表达，靶细胞的DNA仍被降解为核小体大小的片段。因此，由因子剥夺诱导的凋亡早期步骤与细胞毒性T细胞触发的步骤不同，尽管它们共享一个以DNA降解和细胞质膜完整性丧失为特征的共同最终途径。
