Wollina U, Mahrle G
Department of Dermatology, University of Cologne, Germany.
J Dermatol Sci. 1992 May;3(3):145-50. doi: 10.1016/0923-1811(92)90028-a.
Biopsy specimens from lesional psoriatic skin and from normal controls were investigated by immunohistochemistry for the presence of epidermal Merkel cells (MC). MC were defined as epidermal cells expressing simple-type keratins, i.e. nos. 8, 18, and 19. A significant number of MC could be found at the bottom of the rete ridges of psoriatic lesions (about 19.6 MC per square mm skin surface area) and of normal skin (about 14.0 MC per square mm surface area). In contrast to normal skin, MC of psoriatic lesions were positive for synaptophysin (21.7% of simple-type keratin positive epidermal cells, i.e. MC), pancreatic polypeptide (14.8%), somatostatin (7.0%), and chromogranin A (less than 3%). The immunostaining was rather faint though significantly different from normal skin. The findings suggest that in psoriasis, epidermal MC show variations of the expression of neuropeptides compared to normal skin. Since some of the neuropeptides are thought to be involved in hyperproliferation and/or skin immunology, our findings might suggest a functional activity of epidermal MC in psoriatic lesions different from normal controls.
通过免疫组织化学方法，对银屑病皮损和正常对照的活检标本进行检测，以确定表皮默克尔细胞（MC）的存在。MC被定义为表达简单型角蛋白（即8、18和19号角蛋白）的表皮细胞。在银屑病皮损的 rete 嵴底部（每平方毫米皮肤表面积约19.6个MC）和正常皮肤（每平方毫米表面积约14.0个MC）中均可发现大量MC。与正常皮肤相比，银屑病皮损的MC突触素呈阳性（21.7%的简单型角蛋白阳性表皮细胞，即MC）、胰多肽呈阳性（14.8%）、生长抑素呈阳性（7.0%）、嗜铬粒蛋白A呈阳性（小于3%）。免疫染色相当微弱，尽管与正常皮肤有显著差异。这些发现表明，在银屑病中，与正常皮肤相比，表皮MC的神经肽表达存在差异。由于一些神经肽被认为与过度增殖和/或皮肤免疫学有关，我们的发现可能表明银屑病皮损中表皮MC的功能活性与正常对照不同。
