Gissler Mika, Berg Cynthia, Bouvier-Colle Marie-Hélène, Buekens Pierre
National Research and Development Centre for Welfare and Health, Information Division, Helsinki, Finland.
Am J Obstet Gynecol. 2004 Feb;190(2):422-7. doi: 10.1016/j.ajog.2003.08.044.
To test the hypothesis that pregnant and recently pregnant women enjoy a "healthy pregnant women effect," we compared the all natural cause mortality rates for women who were pregnant or within 1 year of pregnancy termination with all other women of reproductive age.
This is a population-based, retrospective cohort study from Finland for a 14-year period, 1987 to 2000. Information on all deaths of women aged 15 to 49 years in Finland (n=15,823) was received from the Cause-of-Death Register and linked to the Medical Birth Register (n=865,988 live births and stillbirths), the Register on Induced Abortions (n=156,789 induced abortions), and the Hospital Discharge Register (n=118,490 spontaneous abortions) to identify pregnancy-associated deaths (n=419).
The age-adjusted mortality rate for women during pregnancy and within 1 year of pregnancy termination was 36.7 deaths per 100,000 pregnancies, which was significantly lower than the mortality rate among nonpregnant women, 57.0 per 100,000 person-years (relative risk [RR] 0.64, 95% CI 0.58-0.71). The mortality was lower after a birth (28.2/100,000) than after a spontaneous (51.9/100,000) or induced abortion (83.1/100,000). We observed a significant increase in the risk of death from cerebrovascular diseases after delivery among women aged 15 to 24 years (RR 4.08, 95% CI 1.58-10.55).
Our study supports the healthy pregnant woman effect for all pregnancies, including those not ending in births.
为验证怀孕及近期怀孕的女性享有“健康孕妇效应”这一假设,我们将怀孕或终止妊娠后1年内的女性的全自然原因死亡率与所有其他育龄女性进行了比较。
这是一项基于人群的回顾性队列研究,研究对象为1987年至2000年期间芬兰的女性,为期14年。从死因登记处获取了芬兰15至49岁女性所有死亡信息(n = 15,823),并将其与医疗出生登记处(n = 865,988例活产和死产)、人工流产登记处(n = 156,789例人工流产)以及医院出院登记处(n = 118,490例自然流产)相链接,以确定与妊娠相关的死亡(n = 419)。
怀孕及终止妊娠后1年内女性的年龄调整死亡率为每100,000例妊娠36.7例死亡,显著低于非怀孕女性的死亡率,即每100,000人年57.0例死亡(相对风险[RR] 0.64,95%置信区间0.58 - 0.71)。分娩后的死亡率(28.2/100,000)低于自然流产(51.9/100,00)或人工流产(83.1/100,00)后的死亡率。我们观察到15至24岁女性分娩后脑血管疾病死亡风险显著增加(RR 4.08,95%置信区间1.58 - 10.55)。
我们的研究支持所有妊娠(包括未分娩的妊娠)存在健康孕妇效应。