微卫星不稳定性在卵巢交界性肿瘤中的作用。

Role of microsatellite instability in borderline ovarian tumors.

作者信息

Sanz Casla M T, Vidaurreta Lazaro M, Almansa de Lara I, Tresserra F, Lopez Marin L, Maestro M L, Dexeus S

机构信息

Laboratory, Biology Department, Hospital Clinico San Carlos, C/Martin Lagos s/n, 28040 Madrid, Spain.

出版信息

Anticancer Res. 2003 Nov-Dec;23(6D):5139-41.

PMID:14981979

Abstract

This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors.

摘要

本研究旨在确定微卫星不稳定性（MSI）在散发性卵巢肿瘤发生发展中的作用。通过比较40例接受散发性卵巢肿瘤手术患者的健康组织和肿瘤组织中的MSI，确定了6个微卫星（BAT25、BAT26、NME1、D17S250、D5S346和D2S123）的不稳定性。在交界性肿瘤中检测到BAT26和D2S123不稳定性，且在卵巢癌中发现微卫星BAT25、NME1和D17S250存在不稳定性。我们的研究结果表明，微卫星不稳定性在散发性卵巢肿瘤的出现或进展中缺乏显著作用。