一名经免疫球蛋白基因重排诊断并确诊为B细胞淋巴瘤的患者出现潘科斯特综合征。

Pancoast's syndrome in a patient with B-cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement.

作者信息

Takahashi Fumiyuki, Ohwada Akihiko, Higashihara Yoshie, Yoshioka Yasuko, Uekusa Toshimasa, Takahashi Kazuhisa, Dambara Takashi, Fukuchi Yoshinosuke

机构信息

Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan.

出版信息

Respirology. 2004 Mar;9(1):137-40. doi: 10.1111/j.1440-1843.2003.00520.x.

DOI:10.1111/j.1440-1843.2003.00520.x

PMID:14982617

Abstract

Pancoast's syndrome due to malignant lymphoma is extremely rare. A case of diffuse large B-cell lymphoma presenting as Pancoast's syndrome is described. A 66-year-old man complained of pain and weakness of the right arm, and CXR revealed a right apical lung tumour. Histological findings were consistent with it being a diffuse large cell type lymphoma and Southern blot analysis revealed clonal rearrangement of the immunoglobulin heavy-chain JH. Thus, the tumour in this patient was diagnosed to be diffuse large B-cell lymphoma. Malignant lymphoma is an extremely rare cause of Pancoast's syndrome and only five cases have been described. This is the first reported case of Pancoast's syndrome caused by B-cell lymphoma, which was accurately diagnosed by analysis of gene rearrangement.

摘要

由恶性淋巴瘤引起的潘科斯特综合征极为罕见。本文描述了一例表现为潘科斯特综合征的弥漫性大B细胞淋巴瘤病例。一名66岁男性主诉右臂疼痛和无力，胸部X线检查显示右肺尖部有肿瘤。组织学检查结果符合弥漫性大细胞型淋巴瘤，Southern印迹分析显示免疫球蛋白重链JH的克隆性重排。因此，该患者的肿瘤被诊断为弥漫性大B细胞淋巴瘤。恶性淋巴瘤是潘科斯特综合征极为罕见的病因，仅报道过5例。这是首例由B细胞淋巴瘤引起的潘科斯特综合征病例，通过基因重排分析得以准确诊断。