Cha Jae-Kwan, Jo Wol-Soon, Shin Hyun Chul, Bae Hae-Rahn, Ho Jeong-Min, Kim Jae Woo
Department of Neurology, College of Medicine, Dong-A University, Busan, South Korea.
Platelets. 2004 Feb;15(1):3-7. doi: 10.1080/09537100310001644024.
Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and collagen. Measurements were made 24 and 72 h and 7 and 90 days after the ischemic event in 29 patients with atherosclerotic ischemic stroke. Platelet aggregability was significantly decreased after 72 h compared to that at 24 h of stroke onset. However, platelet CD63 and P-selectin expression remained high even 90 days after the events. These findings suggest that platelet hyperactivation in atherosclerotic ischemic stroke may be sustained for a considerable period.
血小板活化是动脉粥样硬化血栓形成发病机制中的一个重要过程。然而，动脉粥样硬化性缺血性卒中患者血小板活化的系列变化尚未明确。在本研究中，我们连续检测了29例动脉粥样硬化性缺血性卒中患者血小板CD63和P-选择素的表达以及血小板对ADP和胶原的聚集性。在缺血事件发生后的24小时、72小时、7天和90天进行检测。与卒中发作后24小时相比，72小时后血小板聚集性显著降低。然而，即使在事件发生90天后，血小板CD63和P-选择素的表达仍维持在较高水平。这些发现提示，动脉粥样硬化性缺血性卒中患者的血小板过度活化可能会持续相当长一段时间。
