Ibrahim A E K, Pickering R M, Gawne-Cain M L, King S, Lees P D, Ellison D W
Department of Cellular Pathology, University of Southampton, Southampton University Hospitals NHS Trust, Southampton, UK.
Clin Neuropathol. 2004 Jan-Feb;23(1):8-15.
Non-functioning pituitary adenomas (NFAs) are a distinct group of pituitary adenomas, which comprise approximately 20% of pituitary adenomas. Although most pituitary adenomas are benign, there is a subset of adenomas that behaves in an aggressive fashion, with either invasion of the surrounding structures or recurrence. The aim of this study was to investigate whether the behaviour of NFAs can be predicted using immunohistochemical markers that label proliferating and apoptotic cells, including a new marker for apoptosis (M30 CytoDEATH). This is the first study to analyse both the proliferation labelling index (LI) and the apoptotic index (AI) in NFAs and to correlate the labelling indices of these histological markers with tumor growth rate as measured by 2 postoperative MRI scans.
40 patients in total were included in the study. 20 patients with high growth rate and percentage change in the pituitary adenoma volume as assessed on 2 postoperative MRI scans were age/sex matched to 20 patients with low growth rate or percentage change.
There is no significant statistical difference of the histological and immunohistochemical indices assessed between cases and controls.
The routine assessment of the proliferation and the apoptotic markers used in this study in NFAs has no prognostic value.
无功能垂体腺瘤（NFAs）是垂体腺瘤中的一个独特类型，约占垂体腺瘤的20%。尽管大多数垂体腺瘤是良性的，但有一部分腺瘤具有侵袭性，可侵犯周围结构或复发。本研究的目的是探讨能否使用标记增殖细胞和凋亡细胞的免疫组化标志物，包括一种新的凋亡标志物（M30 CytoDEATH）来预测NFAs的行为。这是第一项分析NFAs增殖标记指数（LI）和凋亡指数（AI），并将这些组织学标志物的标记指数与术后两次MRI扫描测量的肿瘤生长率相关联的研究。
本研究共纳入40例患者。根据术后两次MRI扫描评估，将20例垂体腺瘤体积生长率高和百分比变化大的患者与20例生长率低或百分比变化小的患者进行年龄/性别匹配。
病例组和对照组之间评估的组织学和免疫组化指标无显著统计学差异。
本研究中用于NFAs的增殖和凋亡标志物的常规评估没有预后价值。
