心脏发育中的Cx43间隙连接

Cx43 gap junctions in cardiac development.

作者信息

Lo C W, Wessels A

机构信息

Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

出版信息

Trends Cardiovasc Med. 1998 Aug;8(6):264-9. doi: 10.1016/s1050-1738(98)00018-8.

DOI:10.1016/s1050-1738(98)00018-8

PMID:14987562

Abstract

Studies utilizing knockout and transgenic mouse models revealed an important role for connexin 43 (Cx43) gap junctions in cardiac development. This may involve a quantitative requirement for gap junctions in modulating the development of cardiac crest cells. In addition, studies in humans and Xenopus indicate that Cx43 gap junctions also may play a role in regulating heart laterality. Together, these findings indicate that the perturbation of Cx43 function could play a significant role in specific congenital heart malformations.

摘要

利用基因敲除和转基因小鼠模型进行的研究揭示了连接蛋白43（Cx43）间隙连接在心脏发育中的重要作用。这可能涉及间隙连接在调节心脏嵴细胞发育方面的定量需求。此外，对人类和非洲爪蟾的研究表明，Cx43间隙连接也可能在调节心脏左右不对称性中发挥作用。这些发现共同表明，Cx43功能的扰动可能在特定先天性心脏畸形中起重要作用。