2-氯乙基亚硝基磺酰胺（CENS）与β-环糊精的包合物
Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin.
作者信息
Kadri Mekki, Dhaoui Nabila, Abdaoui Mohamed, Winum Jean-Yves, Montero Jean-Louis
机构信息
Laboratoire de chimie appliquée, Université de Guelma, BP 401, Guelma 24000, Algeria.
出版信息
Eur J Med Chem. 2004 Jan;39(1):79-84. doi: 10.1016/j.ejmech.2003.11.003.
Host-guest association between four CENS (derivated from piperidine, dibenzylamine, dicyclohexylamine and methyl prolinate) and beta-cyclodextrin was carried out in solution and solid state. Characterisation, stoichiometry, solubility, dissociation constants and stability of such complexes were studied, showing that the inclusion with beta-CD appears as a promising mode of formulation of 2-chloroethylnitrososulfamides.
在溶液和固态中进行了四种CENS（衍生自哌啶、二苄胺、二环己胺和脯氨酸甲酯）与β-环糊精之间的主客体缔合。研究了此类配合物的表征、化学计量、溶解度、解离常数和稳定性，结果表明与β-环糊精形成包合物似乎是2-氯乙基亚硝基磺酰胺一种很有前景的制剂形式。
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