N-氨磺酰基恶唑烷酮与β-环糊精的包合物

Inclusion complexes of N-sulfamoyloxazolidinones with beta-cyclodextrin.

作者信息

Kadri Mekki, Djemil Rayenne, Abdaoui Mohamed, Winum Jean-Yves, Coutrot Frédéric, Montero Jean-Louis

机构信息

Laboratoire de Chimie Appliquée, Université de Guelma, BP401, Guelma 24000, Algeria.

出版信息

Bioorg Med Chem Lett. 2005 Feb 15;15(4):889-94. doi: 10.1016/j.bmcl.2004.12.060.

DOI:10.1016/j.bmcl.2004.12.060

PMID:15686881

Abstract

A study of inclusion complexes of six N-sulfamoyloxazolidinone derivatives with beta-cyclodextrin is described. The inclusion complexes were prepared in solution and in solid state with stoichiometry host-guest 1:1, and characterized. In solution, the complexation was carried out by spectrophotometric measurements at 25 degrees C. The stoichiometries and stability constants of complexes at various pHs have been determined using second-derivative spectrophotometry UV-vis. Hydrophobic properties of N-sulfamoyloxazolidinones are improved following their inclusion into beta-CD.

摘要

描述了六种N-氨磺酰基恶唑烷酮衍生物与β-环糊精包合物的研究。包合物在溶液和固态中以1:1的主客体化学计量比制备并进行了表征。在溶液中，于25℃通过分光光度法测量进行络合。使用二阶导数分光光度法紫外可见光谱测定了不同pH值下络合物的化学计量比和稳定常数。N-氨磺酰基恶唑烷酮被包合进β-环糊精后其疏水性能得到改善。