Raffa Demetrio, Daidone Giuseppe, Maggio Benedetta, Cascioferro Stella, Plescia Fabiana, Schillaci Domenico
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy.
Farmaco. 2004 Mar;59(3):215-21. doi: 10.1016/j.farmac.2003.10.004.
3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a-q and 15a-q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a-q and 15a-q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.
通过在乙酸中，将相应的2-甲基喹唑啉酮12和13与合适的苯甲醛回流12小时，合成了3-(1-苯基-3-甲基吡唑-5-基)-2-苯乙烯基喹唑啉-4(3H)-酮14a-q和15a-q。对合成的苯乙烯基喹唑啉酮14a-q和15a-q进行了体外抗白血病活性测试，针对L1210（小鼠白血病）、K562（人慢性髓性白血病）和HL60（人白血病）细胞系，在某些情况下显示出良好的活性。
