Kleinschmidt-DeMasters B K
Department of Pathology, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Denver, CO 80262, USA.
J Neuropathol Exp Neurol. 2004 Feb;63(2):106-12. doi: 10.1093/jnen/63.2.106.
Gamna-Gandy (G-G) bodies are classically defined as spheroidal yellow-brown foci consisting of dense fibrous tissue and collagenous fibers encrusted with iron pigments and calcium salts. These siderotic nodules were first described in the spleen early in the twentieth century and for a short time were considered to be caused by fungal infection due to the presence of unusual "bamboo-like and articulated" fibers in the lesions that vaguely mimicked mycelia forms. This notion was proven to be incorrect in the 1930s and G-G bodies are now considered to result from organization of small hemorrhages. Although originally reported in splenomegaly, G-G bodies are well-recognized findings in atrial myxomas where they form linear arrays of mineral-encrusted fibers, often at the edge of resolving hemorrhages. They rarely have been reported in lymph nodes, thymoma, thyroid adenoma, and renal cell carcinoma. Curiously, published examples of G-G bodies in central nervous system (CNS) neoplasms or vascular malformations have not appeared, despite the known tendency for bleeding, even recurrent episodes of bleeding, in several types of these lesions. Since 1999 I have accrued all the examples of G-G bodies that I have observed in my practice of surgical neuropathology. These cases are presented here and the historical aspects of the entity are reviewed.
甘纳-甘迪（G-G）小体的经典定义为球状黄褐色病灶，由致密纤维组织和包裹着铁色素及钙盐的胶原纤维构成。这些含铁血黄素结节于20世纪初首次在脾脏中被描述，由于病灶中存在异常的“竹节状和关节状”纤维，这些纤维模糊地模仿了菌丝体形态，在短时间内曾被认为是由真菌感染引起的。这一观点在20世纪30年代被证明是错误的，现在认为G-G小体是小出血灶机化的结果。尽管最初是在脾肿大中报道的，但G-G小体在心房黏液瘤中是公认的发现，它们在那里形成矿物质包裹纤维的线性排列，通常位于正在消退的出血灶边缘。它们在淋巴结、胸腺瘤、甲状腺腺瘤和肾细胞癌中的报道很少。奇怪的是，尽管已知几种类型的中枢神经系统（CNS）肿瘤或血管畸形有出血倾向，甚至有反复出血的情况，但尚未有关于G-G小体在这些病变中的公开报道。自1999年以来，我收集了我在外科神经病理学实践中观察到的所有G-G小体病例。现将这些病例呈现于此，并对该实体的历史背景进行回顾。
