通过克隆和测序鉴定出一个新的HLA - DRB111等位基因，即DRB11144。

A new HLA-DRB111 allele, DRB11144, identified by cloning and sequencing.

作者信息

Nesci S, Buffi O, Iliescu A, Luchetti M, Battarra M R, Amadei M, Visani G, Andreani M

机构信息

Laboratorio di Ricerca di Onco-Ematologia, Dipartimento di Onco-Ematologia, Azienda Ospedale 'San Salvatore', Pesaro, Italy.

出版信息

Tissue Antigens. 2004 Mar;63(3):282-3. doi: 10.1111/j.1399-0039.2004.00176.x.

DOI:10.1111/j.1399-0039.2004.00176.x

PMID:14989721

Abstract

We report here the identification of a novel DRB111 allele, DRB11144, identified during sequence-based HLA-DRB1 typing. Molecular cloning and direct sequencing confirmed that the new allele is identical to DRB1*110401 at exon 2, except for a single nucleotide substitution (GTG-->GCG) changing codon 38 from Valine to Alanine.

摘要

我们在此报告在基于序列的HLA - DRB1分型过程中鉴定出的一个新的DRB111等位基因，即DRB11144。分子克隆和直接测序证实，该新等位基因在第2外显子上与DRB1*110401相同，只是有一个单核苷酸替换（GTG→GCG），使第38密码子由缬氨酸变为丙氨酸。