一种预防子宫切除标本中子宫内膜自溶的简单方法。
A simple method for the prevention of endometrial autolysis in hysterectomy specimens.
作者信息
Houghton J P, Roddy S, Carroll S, McCluggage W G
机构信息
Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland, UK.
出版信息
J Clin Pathol. 2004 Mar;57(3):332-3. doi: 10.1136/jcp.2003.012898.
AIMS
Uteri are among the most common surgical pathology specimens. Assessment of the endometrium is often difficult because of pronounced tissue autolysis. This study describes a simple method to prevent endometrial autolysis and aid in interpretation of the endometrium.
METHODS
Sixty uteri were injected with formalin using a needle and syringe directed alongside a probe, which was inserted through the external cervical os into the endometrial cavity. Injection was performed on the same day as removal of the uterus. As controls, 60 uteri that were not injected with formalin were examined. The degree of endometrial autolysis was assessed on a four point scale (0-3), with a score of 0 representing no or minimal autolysis and a score of 3 representing extensive autolysis, such that histological interpretation of the endometrium was impossible.
RESULTS
In the injected group, the number of cases with scores of 0, 1, 2, and 3 was 42, 13, four, and one, respectively. The corresponding values for the control group were 17, 23, eight, and 12, respectively. This was highly significant (p < 0.001)
CONCLUSIONS
There was significantly less endometrial autolysis in uteri injected with formalin. The use of this simple procedure should be encouraged in hysterectomy specimens.
目的
子宫是最常见的外科病理标本之一。由于组织自溶明显，对子宫内膜的评估往往很困难。本研究描述了一种预防子宫内膜自溶并有助于解读子宫内膜的简单方法。
方法
使用针筒沿探头将福尔马林注入60个子宫，探头经宫颈外口插入子宫内膜腔。在切除子宫的同一天进行注射。作为对照，检查60个未注射福尔马林的子宫。子宫内膜自溶程度按4分制（0 - 3）评估，0分表示无或极少自溶，3分表示广泛自溶，以至于无法对子宫内膜进行组织学解读。
结果
注射组中，得0分、1分、2分和3分的病例数分别为42、13、4和1。对照组的相应数值分别为17、23、8和12。差异具有高度显著性（p < 0.001）。
结论
注射福尔马林的子宫中子宫内膜自溶明显较少。在子宫切除标本中应鼓励使用这种简单方法。
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