Yuan P X, Si L S
Department of Pathology, Xian Medical University.
Zhonghua Bing Li Xue Za Zhi. 1992 Apr;21(2):88-91.
Infiltrating mononuclear cell (MNC) subsets and transferrin receptor (TfR) expression at the localized lesions were studied in 28 cases of gastric carcinoma and 36 cases of colorectal carcinoma by immunohistochemical technique by using a panel of monoclonal antibodies. The results showed that the percentage of T4+ cells in the infiltrating MNCs decreased while that of T8+ cells increased relatively and the T4/T8 ratios declined along with the progression of the tumor. The TfR positive rates in gastric and colorectal carcinomas were 73.08% and 100% respectively. The expressing intensity of TfR in the tumors correlated with the density of local infiltrating MNC subsets. These findings indicated that the local immune response against tumor moves toward a tendency of developing a deeper inhibitory effect during the tumor progression.
采用一组单克隆抗体，通过免疫组织化学技术对28例胃癌和36例结直肠癌局部病灶中的浸润单核细胞（MNC）亚群及转铁蛋白受体（TfR）表达进行了研究。结果显示，随着肿瘤进展，浸润MNC中T4+细胞百分比下降，T8+细胞百分比相对增加，T4/T8比值降低。胃癌和结直肠癌中TfR阳性率分别为73.08%和100%。肿瘤中TfR的表达强度与局部浸润MNC亚群的密度相关。这些发现表明，肿瘤进展过程中针对肿瘤的局部免疫反应朝着产生更强抑制作用的趋势发展。
