多巴胺和多巴酚丁胺对用低氧混合气体通气的犬低氧肺血流动力学反应的比较效应。

Comparative effects of dopamine and dobutamine on the pulmonary haemodynamic response to hypoxia in dogs ventilated with a hypoxic gas mixture.

Tanaka H, Tajimi K, Kasai T, Kobayashi K

Trauma and Critical Care Center, Teikyo University School of Medicine, Tokyo, Japan.

Clin Exp Pharmacol Physiol. 1992 Jul;19(7):517-22. doi: 10.1111/j.1440-1681.1992.tb00498.x.

Abstract

The effects of dopamine and dobutamine on the pulmonary haemodynamic response to hypoxia were studied in nine anaesthetized dogs under hypoxaemia induced by ventilation with hypoxic gas mixture. 2. From the present study, only dopamine infusion reduced arterial oxygenation during hypoxic hypoxaemia, whereas catecholamine maintained it at the same level during normoxaemia. 3. A redistribution of perfusion to the pulmonary vasculature may be related to a reduction of arterial oxygenation with dopamine infusion during hypoxic hypoxaemia. 4. It is presumed that an increase in pulmonary blood flow would emphasize an inhibition of hypoxic pressor response in the pulmonary vasculature, which may not be a direct effect of dopamine.

摘要

在9只麻醉犬中，通过使用低氧混合气体通气诱导低氧血症，研究了多巴胺和多巴酚丁胺对低氧性肺血流动力学反应的影响。2. 从本研究来看，仅多巴胺输注在低氧性低氧血症期间降低了动脉氧合，而儿茶酚胺在正常氧血症期间将其维持在相同水平。3. 在低氧性低氧血症期间，肺血管灌注的重新分布可能与多巴胺输注导致的动脉氧合降低有关。4. 据推测，肺血流量增加会加重对肺血管低氧升压反应的抑制，这可能不是多巴胺的直接作用。